Contrastive Regulatory Embeddings Attention Model for Differential Expression Prediction with Personalized Genomes: Insights and Challenges

Deep learning models applied to DNA sequences have achieved success in predicting gene expression, chromatin profiles, and variant pathogenicity.

Deep learning models applied to DNA sequences have achieved success in predicting gene expression, chromatin profiles, and variant pathogenicity. However, learning cross-individual differences remains challenging because DNA sequence variation between individuals is small, while…