Isthmin-2 is a first-trimester predictor of preeclampsia and fetal growth restriction.

Preeclampsia and fetal growth restriction (FGR) are major causes of global morbidity and mortality.

Preeclampsia and fetal growth restriction (FGR) are major causes of global morbidity and mortality. Both conditions are associated with impaired invasion of the uterus by extravillous trophoblast (EVT). We performed proteomics in maternal serum obtained at ~12 weeks of…