PKD2L1 channels segregated to the apical compartment are the dual-mode pH sensor in cerebrospinal fluid-contacting neurons.

Cerebrospinal fluid contacting neurons (CSFcNs) are GABAergic cells that surround the central canal (cc) of the spinal cord.

Cerebrospinal fluid contacting neurons (CSFcNs) are GABAergic cells that surround the central canal (cc) of the spinal cord. Their soma is located sub-ependymally and they have a dendritic-like process that ends as a bulb (the so-called apical process; ApPr) inside the cc. It…