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Science & ResearchJul 25, 2026

Intrafilament nucleotide exchange in a prokaryotic actin homolog

Polymerisation and disassembly govern the cellular functions of cytoskeletal proteins.

Polymerisation and disassembly govern the cellular functions of cytoskeletal proteins. In canonical nucleotide-dependent polymers such as actin and tubulin, nucleotide exchange occurs in soluble subunits but not within intact protofilaments. By contrast, the assembly dynamics…

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