Transcription Start Site Heterogeneity Confounds the Landscape and Functional Interpretation of uORFs

Upstream open reading frames (uORFs) are predicted in over half of the genes in many eukaryotes and often reduce translation and mRNA stability.

Upstream open reading frames (uORFs) are predicted in over half of the genes in many eukaryotes and often reduce translation and mRNA stability. This raises a paradox: why do uORFs remain so prevalent in eukaryotic genomes despite their repressive effects on gene expression?…