Increased expression of developmental Nav1.3 promotes hippocampal CA3 hyperexcitability in early-stage 5xFAD mice

Neuronal hyperexcitability is an early and pervasive feature of Alzheimers disease (AD) that both predicts and accelerates subsequent cognitive decline.

Neuronal hyperexcitability is an early and pervasive feature of Alzheimers disease (AD) that both predicts and accelerates subsequent cognitive decline. Persistent excitability depends on activation of voltage-gated sodium channels (Nav), yet most work has focused on the Nav…