Xylose phosphatase activity of dystroglycan self-regulates its receptor function.

Dystroglycan (DG) is an extracellular matrix receptor crucial for tissue development and pathogen entry.

Dystroglycan (DG) is an extracellular matrix receptor crucial for tissue development and pathogen entry. DG harbors a long, complex glycan called matriglycan. Loss of matriglycan or reduction in its length disrupts DG function, causing dystroglycanopathies. However, the…