Asymmetric co-substrate usage at a metabolic branch point as a minimal network motif that can drive overflow metabolism

Metabolic overflow is pervasive from microbes to tumors: as glucose consumption increases, cells switch from respiration to respirofermentation with excretion of organic acids or ethanol.

Metabolic overflow is pervasive from microbes to tumors: as glucose consumption increases, cells switch from respiration to respirofermentation with excretion of organic acids or ethanol. How do cells regulate their fluxes to implement this switch? Using simplified models of a…