Intestinal stem cells count self-renewal divisions to switch multipotency.

Multipotent stem cells maintain tissue homeostasis by producing distinct daughter cell types in defined proportions 1,2 , but how they coordinate type-specific ratios during repeated divisions remains unknown.

Multipotent stem cells maintain tissue homeostasis by producing distinct daughter cell types in defined proportions 1,2 , but how they coordinate type-specific ratios during repeated divisions remains unknown. Drosophila intestinal stem cells (ISCs) switch between producing…