Alternative splicing expands and remodels the breast cancer proteoform landscape

AbstractAlternative splicing generates transcript diversity, but how much reaches the translated proteome and how it reshapes protein regulation remain unclear.

AbstractAlternative splicing generates transcript diversity, but how much reaches the translated proteome and how it reshapes protein regulation remain unclear. Here, we develop 3DisoGalaxy, an atlas integrating transcript reconstruction, ribosome profiling, structural modelling…