Dynamic dimer-of-dimers architecture defines Mg 2+ transport in human CNNM4.

Mg 2+ is essential for all living organisms, yet its transport across mammalian membranes remains poorly understood.

Mg 2+ is essential for all living organisms, yet its transport across mammalian membranes remains poorly understood. Here, we present cryoelectron microscopy (cryo-EM) structures of a full-length mammalian Mg 2+ transporter on the plasma membrane, human CNNM4, in outward-facing…