Science & ResearchJul 23, 2026
A 3D genome atlas of human tonsil and the role of loop extrusion in B cell somatic hypermutation.
B cell maturation within the germinal center tissue microenvironment involves immunoglobulin gene diversification by somatic hypermutation (SHM).
B cell maturation within the germinal center tissue microenvironment involves immunoglobulin gene diversification by somatic hypermutation (SHM). How three-dimensional (3D) genome architecture influences SHM is not fully understood. We leveraged sequencing-based and image-based…
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