Reconstructing sequence-grammar trajectories enables interpretable and tunable cis-regulatory element design

Designing synthetic cis-regulatory elements (CREs) with cell-type-specific activity is critical for precision gene and cell therapies, but remains challenging because optimization is often treated as a black box, obscuring how regulatory…

Designing synthetic cis-regulatory elements (CREs) with cell-type-specific activity is critical for precision gene and cell therapies, but remains challenging because optimization is often treated as a black box, obscuring how regulatory grammar emerges and how failed…