Science & ResearchAug 6, 2026
The N-Terminus of Sophora tonkinensis Cytochrome P450s Evolves Neutrally yet Encodes Rich Functional Information: A Protein Language Model Analysis
The N-terminal membrane anchor of cytochrome P450s is essential for function yet exceptionally variable--a paradox resistant to alignment-based analysis.
The N-terminal membrane anchor of cytochrome P450s is essential for function yet exceptionally variable--a paradox resistant to alignment-based analysis. Using an alignment-free protein language model (ESM2) pipeline on 345 Sophora tonkinensis P450s, we show the N-terminal 50…
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