Evolutionary divergence V-ATPase function in macropinocytic cup remodeling

Macropinocytosis is an evolutionarily conserved process from unicellular eukaryotes to mammals.

Macropinocytosis is an evolutionarily conserved process from unicellular eukaryotes to mammals. This process relies on actin-rich protrusions beneath the plasma membrane to form a macropinocytic cup. Traditionally, V ATPase has been best studied for its role in late endosomal…