Science & ResearchJul 21, 2026
A hybrid machine learning and enzyme-constrained metabolic model for ab initio prediction of proteome reallocation
High expression of heterologous proteins in microbial cell factories frequently triggers a severe burden due to reallocation of finite cellular proteome.
High expression of heterologous proteins in microbial cell factories frequently triggers a severe burden due to reallocation of finite cellular proteome. Conventional constraint-based models struggle to predict these resource shifts ab initio without relying on…
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