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Science & ResearchAug 4, 2026

Tau reduction counteracts transcriptomic and behavioral abnormalities in an Alzheimer amyloid model

Alzheimers disease (AD) causes amyloid formation, neuritic dystrophy, gliosis, synapse loss, behavioral abnormalities, and weight loss.

Alzheimers disease (AD) causes amyloid formation, neuritic dystrophy, gliosis, synapse loss, behavioral abnormalities, and weight loss. 5xFAD transgenic mice simulate these alterations. To further investigate overall tau reduction as a therapeutic strategy for AD-related…

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