Science & ResearchJul 18, 2026
LeafRank: A phylodynamic framework for inferring relative fitness from single-cell phylogenies in chromosomally unstable tumors
Tumors contain cancer cells with diverse growth potentials that shape evolutionary trajectories, yet this fitness diversity remains difficult to quantify in cases of whole-genome duplication (WGD) and chromosomal instability.
Tumors contain cancer cells with diverse growth potentials that shape evolutionary trajectories, yet this fitness diversity remains difficult to quantify in cases of whole-genome duplication (WGD) and chromosomal instability. We present LeafRank, a mathematical framework that…
Sign in to learn & save →
The frontier is open to all. Sign in to learn this from first principles and save it to your knowledge base.