Chemoselective Bioconjugation Reveals Norepinephrinylation (NEylation) as a Widespread Post-Translational Modification in Cells

Norepinephrine (NE) is a key neurotransmitter and hormone involved in diverse physiological and pathological processes.

Norepinephrine (NE) is a key neurotransmitter and hormone involved in diverse physiological and pathological processes. Beyond its canonical non-covalent signaling through binding adrenergic receptors, NE also induces protein post-translational modifications (PTMs), representing…