Nanoscale Core-Rim Compartmentalization of Histamine and GABA within Individual Synaptic Vesicles

Classical synaptic transmission assumes that amino acid neurotransmitters and monoamines are stored in distinct vesicle populations.

Classical synaptic transmission assumes that amino acid neurotransmitters and monoamines are stored in distinct vesicle populations. Here, we provide structural evidence for a dual-transmitter organization in which histamine and GABA are spatially partitioned into a core and rim…