Chromatin remodeling protein CHD4 regulates axon guidance of spiral ganglion neurons in developing cochlea

Spiral ganglion neurons (SGNs) are the primary afferent neurons that convey auditory information from the cochlea to the central nervous system.

Spiral ganglion neurons (SGNs) are the primary afferent neurons that convey auditory information from the cochlea to the central nervous system. Pathogenic variants of human chromodomain helicase DNA-binding protein 4 (CHD4) cause Sifrim-Hitz-Weiss (SIHIWES) syndrome, a…