Pathway-specific short-term synaptic dynamics and lateral inhibition shape frequency-dependent input integration and population-level pattern separation in the dentate gyrus

The dentate gyrus (DG) decorrelates overlapping entorhinal inputs into distinct granule-cell representations, a computation central to pattern separation and to reducing interference in episodic memory.

The dentate gyrus (DG) decorrelates overlapping entorhinal inputs into distinct granule-cell representations, a computation central to pattern separation and to reducing interference in episodic memory. The three excitatory pathways to granule cells -- the lateral perforant path…